One of the tricks to improving the open rate for your emails is to send them at a time when you subscribers are more likely to be checking their emails. That means you need to access analytics. Those will tell you when your emails get opened by whom, and whether that varies from region to region. 

Then you can use that information to time your email campaigns. It might be that you’re able to set your emails to send out all at a single point in time. If that’s the case, then your job is easy. Otherwise, you might want to batch send your emails based on where the recipients are located. For example, you might want to send emails to Europe at one time, to Australia at another time, and to the United States, Canada, and Mexico at a third time. If that’s the case, you’ll want an email management software service that can do just that.